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Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas

Bipolar Mood Shifts Linked to Insulin Signaling in the Pancreas
health8/16/2025

A new study uncovers a pancreas–hippocampus feedback loop that may help explain mood swings in bipolar disorder.

Summary: A new study uncovers a pancreas–hippocampus feedback loop that may help explain mood swings in bipolar disorder. Using patient-derived pancreatic islets, researchers found reduced insulin secretion linked to elevated RORβ, a bipolar risk gen... [7574 chars]