Beyond Post-tuberculosis Sequelae: Uncovering Common Variable Immunodeficiency in an Adult

Common variable immunodeficiency (CVID) is a rare immunodeficiency syndrome presenting with wide manifestations and leading to a delayed diagnosis. A 40-year-old male, a case of old treated tuberculosis, presented with a productive cough and hemoptysis. He had a history of recurrent respiratory symptoms previously attributed to post-tuberculosis sequelae with bilateral bronchiectasis, which can also occur as a manifestation of underlying common variable immunodeficiency (CVID). After a detailed evaluation, serum immunoglobulin levels were markedly reduced, confirming CVID. The patient was started on intravenous immunoglobulin (IVIG) therapy every month. After a six-month follow-up, the patient was symptomatically better and had reduced hospitalizations.